Scientists Use CRISPR to Condense a Million Years of Evolution Into Mere Months [My Love Tech, September 2022]

Title:

Scientists Use CRISPR to Condense a Million Years of Evolution Into Mere Months

 

By:

raisamiullah327 

 

Published:

My Love Tech, 11 September 2022

https://mylovetech.com/scientists-use-crispr-to-condense-a-million-years-of-evolution-into-mere-months/

 

From the article:

Made in a lab in Beijing, Xiao Zhu pushes the boundary of what’s doable for genetic engineering and artificial biology. Moderately than harboring the same old 20 pairs of chromosomes, the mouse and its sibling cohorts solely have 19 pairs.

 

ALSO SEE

 

Li-Bin Wang (et al.) August 2022. A sustainable mouse karyotype created by programmed chromosome fusion. Science, 3777(6609), pp. 967-975.

https://www.science.org/doi/10.1126/science.abm1964

 

University of Illinois, USA - A ‘Factory Reset’ for the Brain Could Cure Anxiety and Drinking Behavior [Neuroscience, May 2022]

Title:

A ‘Factory Reset’ for the Brain Could Cure Anxiety and Drinking Behavior

 

Source:

University of Illinois,Chicago, USA

Published:

Neuroscience, 7 May 2022

https://neurosciencenews.com/anxiety-aud-gene-editing-20540/

 

From the article:

Gene editing may be a potential treatment for anxiety and alcohol use disorder in adults who were exposed to binge drinking in their adolescence, according to the results of an animal study published in the journal Science Advances.

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 [Scholarly Article - IJVTPR, May 2021]

Title:

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 

 

Authors:

Stephanie Seneff

Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge MA, 02139, USA

 & 

Greg Nigh

Naturopathic Oncology, Immersion Health, Portland, OR 97214, USA 

 

Published:

International Journal of Vaccine Theory, Practice, and Research (IJVTPR), 2(1), 10 May 2021

https://ijvtpr.com/index.php/IJVTPR/article/view/23

 

Abstract: 

Operation Warp Speed brought to market in the United States two mRNA vaccines, produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these vaccines, which helped legitimize Emergency Use Authorization (EUA) by the FDA. However, the exceptionally rapid movement of these vaccines through controlled trials and into mass deployment raises multiple safety concerns. In this review we first describe the technology underlying these vaccines in detail. We then review both components of and the intended biological response to these vaccines, including production of the spike protein itself, and their potential relationship to a wide range of both acute and long-term induced pathologies, such as blood disorders, neurodegenerative diseases and autoimmune diseases. Among these potential induced pathologies, we discuss the relevance of prion-protein-related amino acid sequences within the spike protein. We also present a brief review of studies supporting the potential for spike protein “shedding”, transmission of the protein from a vaccinated to an unvaccinated person, resulting in symptoms induced in the latter. We finish by addressing a common point of debate, namely, whether or not these vaccines could modify the DNA of those receiving the vaccination. While there are no studies demonstrating definitively that this is happening, we provide a plausible scenario, supported by previously established pathways for transformation and transport of genetic material, whereby injected mRNA could ultimately be incorporated into germ cell DNA for transgenerational transmission. We conclude with our recommendations regarding surveillance that will help to clarify the long-term effects of these experimental drugs and allow us to better assess the true risk/benefit ratio of these novel technologies. 

 

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 [Scholarly Article - International Journal of Vaccine Theory, Practice, and Research, 2021]

Title:

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19

 

Authors:

Stephanie Seneff

Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge MA. 02139, USA

&

Greg Nigh

Naturopathic Oncology, Immersion Health, Portland, OR 97214, USA

 

Published:

International Journal of Vaccine Theory, Practice, and Research, Volume 2, Number 1 (2021): Epidemic NCDs, https://ijvtpr.com/index.php/IJVTPR/article/view/23

 

Abstract:

Operation Warp Speed brought to market in the United States two mRNA vaccines, produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these vaccines, which helped legitimize Emergency Use Authorization (EUA) by the FDA. However, the exceptionally rapid movement of these vaccines through controlled trials and into mass deployment raises multiple safety concerns. In this review we first describe the technology underlying these vaccines in detail. We then review both components of and the intended biological response to these vaccines, including production of the spike protein itself, and their potential relationship to a wide range of both acute and long-term induced pathologies, such as blood disorders, neurodegenerative diseases and autoimmune diseases. Among these potential induced pathologies, we discuss the relevance of prion-protein-related amino acid sequences within the spike protein. We also present a brief review of studies supporting the potential for spike protein “shedding”, transmission of the protein from a vaccinated to an unvaccinated person, resulting in symptoms induced in the latter. We finish by addressing a common point of debate, namely, whether or not these vaccines could modify the DNA of those receiving the vaccination. While there are no studies demonstrating definitively that this is happening, we provide a plausible scenario, supported by previously established pathways for transformation and transport of genetic material, whereby injected mRNA could ultimately be incorporated into germ cell DNA for transgenerational transmission. We conclude with our recommendations regarding surveillance that will help to clarify the long-term effects of these experimental drugs and allow us to better assess the true risk/benefit ratio of these novel technologies.

Human germline editing: Legal-ethical guidelines for South Africa [Scholarly Article - South African Journal of Science, 2020]

Title:

Human germline editing: Legal-ethical guidelines for South Africa

 

Authors:

Donrich Thaldar, Marietjie Botes, Bonginkosi Shozi, Beverley Townsend & Julian Kinderlerer

[All from the University of KwaZulu-Natal, South Africa]

Published:

South African Journal of Science, Volume 116, Number 10 (2020)

https://www.sajs.co.za/article/view/6760

Abstract:

Human germline editing holds much promise for improving people’s lives, but at the same time this novel biotechnology raises ethical and legal questions. The South African ethics regulatory environment is problematic, as it prohibits all research on, and the clinical application of, human germline editing. By contrast, the South African legal regulatory environment allows a regulatory path that would, in principle, permit research on human germline editing. However, the legal regulation of the clinical application of human germline editing is uncertain. As such, the current ethical and legal positions in South Africa are in need of reform. Five guiding principles – aligned with the values of the Constitution – are proposed to guide ethical and legal policy reform regarding human germline editing in South Africa: (1) Given its potential to improve the lives of the people of South Africa, human germline editing should be regulated, not banned. (2) Human germline editing clinical applications should only be made accessible to the public if they are proven to be safe and effective. (3) Non-therapeutic human germline editing may be permissible, and should be regulated in the same way as therapeutic human germline editing. (4) The decision on whether to use germline gene editing on a prospective child, should, subject to Principle 2, be left to the prospective parents. (5) Concerns about exacerbating social inequalities should be addressed by measures to increase access. In conclusion, recommendations are made to policymakers and scientists contemplating research in this field.