Title:
Immunological memory to SARS-CoV-2 assessed for greater than six months after infection
Authors:
Jennifer M Dan, Jose Mateus, Yu Kato, Kathryn M Hastie, Caterina Faliti, Sydney I Ramirez, April Frazier, Esther D Yu, Alba Grifoni, Stephen A Rawlings, Bjoern Peters, Florian Krammer, Viviana Simon, Erica O Saphire, Davey Smith, Daniela Weiskopf, Alessandro Sette & Shane Crotty
Published:
bioRxiv, 16 November 2020
[Keep in mind that this is a preprint and not yet peer reviewed.]
Abstract:
Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 185 COVID-19 cases, including 41 cases at > 6 months post-infection. Spike IgG was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.